The Nucleus Accumbens is one of the basal ganglia and has been implicated of the pathophysiology of disorders such as depression and schizophrenia. It’s involvement in these disorders is fundamentally due to its role in the cortico-gangliathalamic loop. The Nucleus Accumbens receives dopaminergic inputs critically important in…
The caudate forms the medial part of the striatum and has clear involvement with both cognitive and motor functions. Damage to this structure has been reported to produce a ‘schizophrenia-like’ state, and so has been the subject of some investigation. As with the adjacent putamen, the caudate receives dopaminergic input from…
Historically the putamen has been known to have a key role in regulating motor function. However in recent years the importance of this nucleus in cognitive functions has become more understood, with a rough dorso-ventral distribution of…
The substantia nigra (SN) is a paired midbrain structure that lies immediately ventral to the cerebral peduncles at the level of the superior colliculus and has a critical regulatory role in…
Scientists at The University of Nottingham have shown that psychotic symptoms experienced by people with schizophrenia could be caused by a faulty ‘switch’ within the brain. In a study published today in the leading journalNeuron, they have demonstrated that the severity of symptoms such as delusions and hallucinations which are typical in patients with the […]
Join us at the Intercontinental in Berlin for the 7th Biennial Congress of The International Society of Affective Disorders, 28th – 30th April, 2014.
Dr. Matthew Williams Visiting research associate in neuroscience at the MRC clinical sciences centre at Hammersmith Hospital and The Insitute of Pyschiatry at Denmark Hill. Much of the research on schizophrenia in recent years has focused on
Researchers at Boston University School of Medicine (BUSM) have uncovered important clues about a biochemical pathway in the brain that may one day expand treatment options for schizophrenia. The study, published online in the journal Molecular Pharmacology, was led by faculty within the department of pharmacology and experimental therapeutics at BUSM.
A model using three patient characteristics was a significant predictor of general neurocognitive impairment in patients 3 years after their first episode of a nonaffective psychosis was diagnosed, in a study conducted in Spain.
The National Institute of Mental Health is putting its research and clinical muscle into determining whether early intervention in schizophrenia can improve outcomes later in life.
Many older adults with a history of chronic schizophrenia can have a sustained remission if they receive appropriate psychosocial stimulation and support, according to Dr. Dilip V. Jeste.
The rs1344706 SNP on the ZNF804a gene was found to correlate with the volume of cortical white matter in schizophrenia patients and healthy control subjects, according to a report published Sept. 3 in Archives of General Psychiatry.
Patients with schizophrenia who are heavy cigarette smokers are more likely to use substances such as alcohol than are those with the disease who are non–heavy smokers. Heavy smokers also are more likely to have elevated cholesterol, a retrospective analysis of 745 patient records has found.
Symptoms of obsessive-compulsive disorder preceded symptoms of schizophrenia in 48% of 133 patients hospitalized over an 11-year period who had both disorders.
Among patients having their first episode of schizophrenia, suicidality is clearly associated with an altered sense of self, or what some experts have termed “self-disorders,” a study of 49 adult patients shows.
Illicit drug use is common among heavy cigarette smokers in the general population, but among outpatients with schizophrenia who are heavy smokers, it is most common in the first decade of illness, according to findings from a study of 70 patients and 97 controls.
Interest in the use of intranasal oxytocin for the treatment of psychiatric disorders has expanded in recent years, and several new studies suggest that it may have benefit in patients with schizophrenia.
Many children with oppositional defiant disorder but not autism nevertheless exhibit elevated symptoms of autism spectrum disorder as well as schizophrenia spectrum disorder.
The estrogen hypothesis of schizophrenia holds that estrogen has a protective, mitigating effect on schizophrenia in women, and that this helps explain why women tend to present with first episodes later in life, present less frequently than men, and, some studies have found, have better prognosis and treatment response.
Long-acting, injectable formulations of antipsychotic drugs significantly boosted treatment compliance in patients with schizophrenia in a review of reimbursement records for more than 3,600 patients.
Schizophrenia patients who underwent 80 hours of computerized training showed significant and sustained improvements in the ability to distinguish between internal experience and outside reality, a group of researchers has shown.
Schizophrenia with comorbid panic disorder, also known as panic psychosis, appears to be a distinct subtype of schizophrenia, according to a study published in Psychiatry Research.
People with schizophrenia are more likely to report having had a wide range of unhappy childhood experiences than are healthy, age-matched controls, a group of Australian researchers has found.
Treatment with metformin led to striking resolution of amenorrhea in women with schizophrenia treated with an antipsychotic drug, in a randomized, controlled study with 84 patients.
High-functioning patients with schizophrenia experienced “mind-pops” significantly more often than did two control groups in a preliminary study exploring a possible connection between these benign cognitive phenomena and hallucinations, according to a report published online in Psychiatry Research.