The Papez circuit in schizophrenia 1: Neuropathological changes

Author:Matthew Williams
Volume Info:Volume 6 January 2021
Article Information

Volume 6 January 2021, pages 52-71
Received:24th November 2020; Accepted: 27th November 2020

Matthew Williams
Visiting Research Associate, Department of Medicine, Imperial College London, Hammersmith Hospital, W12 0NN, UK.


The Papez circuit was first described in 1937 as a potential enclosed system within the brain for emotional regulation. Since then the emotional role of the circuit has not received good support from laboratory investigation, the circuits roles in memory has become clear. As the clinical presentation of schizophrenia often includes symptoms related to the relevant functional roles of the constituent structures and also various memory problems this first paper reviews the neuropathological evidence for change in the constituent neurological structures of the Papez circuit, with additional information from modern imaging sciences.


Papez, Thalamus, Hippocampus, Cingulate, Mamillary, Schizophrenia



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