Embolic Stroke of Undetermined Source (ESUS)

Author:Ales Tomek
Volume Info:Volume 4 Issue 1
Article Information

Volume 4 Issue 1, pages 92-97
Received – 12 July 2018, Accepted – 20 July 2018


Neurology Department, 2nd Medical Faculty, Charles University and Motol University Hospital, Prague, Czech Republic


Corresponding Author: Ales Tomek – ales.tomek@lfmotol.cuni.cz


Embolic stroke of undetermined source (ESUS) is a subset of cryptogenic stroke. Recurrence rates are high following ESUS and the optimal treatment to reduce the risk of recurrent stroke depends on the pathophysiology of the index stroke. Because of the composition of emboli, anticoagulants may be a better treatment option than antiplatelet therapy in secondary stroke prevention. This article reviews recent and ongoing clinical trials evaluating antithrombotic treatments in the setting of ESUS, examines differences among the trials, and discusses the implications of anticoagulation in ESUS.


Acknowledgements: The editorial assistance of Thistle Editorial, LLC in the preparation of this article is acknowledged with thanks.


ESUS, stroke, NOACs, anticoagulation



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