C9orf72-Associated Frontotemporal Dementia And Psychosis
Volume 3 Issue 1 , pages 42-45
Published July 2017
Department of Psychiatry. Alto Minho Local Health Unit. Viana do Castelo, Portugal.
Department of Neurology. Hospital Pedro Hispano, Matosinhos Local Health Unit. Matosinhos, Portugal.
Department of Clinical Neurosciences and Mental Health. Faculty of Medicine University of Porto. Porto, Portugal.
Corresponding Author: João Massano – firstname.lastname@example.org
Frontotemporal dementia (FTD) is a progressive neurodegenerative disease. About 30-40% of the cases have a positive family history, and genetic mutations are identifiable in an increasing proportion of cases. Although psychosis in FTD has been recognized for many years, it has not been taken as a key feature, and has not been included in the clinical diagnostic criteria.
Key words: Frontotemporal dementia; Frontotemporal lobar degeneration; C9orf 72; TDP-43; psychosis; neuropathology.
bvFTD- behavioral variant Frontotemporal dementia
C9orf 72- Chromosome 9 open reading frame 72
CBD- Corticobasal degeneration
CBS- Corticobasal syndrome
CHMP2b- Charged Multivesicular Body Protein 2B
FTD- Frontotemporal dementia
FUS- Fused in sarcoma
MAPT- Microtubule associated protein tau
MND- Motor neuron disease PNFA- Progressive Non-Fluent Aphasia
PSP- Progressive supranuclear palsy
SD- Semantic dementia
TARDBP- Transactive response DNA binding protein
TDP-43- Transactive response DNA binding protein 43 kDa
VCP- Valosin-containing protein