Optogenetic Manipulation Of The Cholinergic System: Potential Implications For The Treatment Of Memory Deficits In Alzheimer’s Disease

Author:Marian Tsanov
Volume Info:Volume 1 Issue 1
Article Information

Volume 1 Issue 1 , pages 40-54
Published May 2015


Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland

School of Psychology, Trinity College Dublin, Ireland


Corresponding Author: tsanovm@tcd.ie


Successful treatment of psychiatric disorders and neurodegenerative diseases depends crucially on our fundamental knowledge of how information is processed and stored by the brain. Understanding the interaction between neuromodulation and signal encoding would essentially aid the progress of their treatment. Given the reciprocal connections between cholinergic and hippocampal networks, it is important to investigate their functional effect on the symptoms of memory impairment. The convergence between neuromodulatory models and behavioral research is finally possible due to tremendous growth of physiological data about neuronal signal processing, as well as external control over of local circuits via electrical microstimulation and optogenetically triggered activation. Optical neural control therapy is an emerging tool in neuroscience that targets the fundamental understanding and treating of a wide range of brain-based disorders. Although this methodology is currently developed on a basic neuroscience level, the latest advances in optogenetics are successfully applied for primate research and pre-clinical testing.

Acknowledgments: This work was supported by Science Foundation Ireland, the Health Research Board and the Wellcome Trust under Biomedical Research Partnership with grant number: 099926/Z/12/Z to Marian Tsanov.


acetylcholine, Optogenetics, Episodic memory, Alzheimer’s disease, Medial septum



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