Amyotrophic lateral sclerosis (ALS) is a motor neuron disease whose pathophysiological deficits causing impairment
in motor function are largely unknown. Recently, our group has found significant high levels of H2S in the liquor of 37
ALS sporadic patients and in tissues and media from the spinal cord cultures bearing the familial ALS (fALS) mutation
SOD1G93A (Davoli et al., 2015). Hydrogen sulphide (H2S) has been considered a physiological messenger alike the
gasotransmitters nitric oxide and carbon monoxide as well as a novel neuromodulator exerting neuroprotective
effects in the brain. Experimentally it is evident that the effect of…