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Mania With Depressive Symptoms: A Pathophysio-Logical Review

Key messages

Bipolar disorder (BD) is a common, complex, and costly psychiatric illness that can be devastating for the

affected individual and their families. Suicide is an important risk across the life span of bipolar patients.

Accurate diagnosis is not easy, particularly in mixed states. Psychotic symptoms may suggest schizophrenia,

and a major depressive episode may appear to be unipolar depression. Comorbid anxiety and substance/

alcohol abuse often…

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