Cerebrospinal Fluid Prognostic Biomarkers In Multiple Sclerosis

Volume 1 Issue 2
Article Information


Multiple sclerosis (MS) is a chronic autoimmune and disabling disease affecting the central nervous system (CNS)
of unknown etiology. As a diagnostic marker for MS does not exist, prognostic biomarkers of disease severity
become clinically relevant. Several CSF biomarkers related to the pathogenesis of brain lesions of MS are displayed.
Neurofilament light protein, glial fibrillary acidic protein, and chitinase 3-like 1 protein are presented as future useful clinical markers in MS. Difficulties in performing and comparing studies of biomarkers in MS are discussed.

Key words: Multiple sclerosis, CHI3L1, GFAP, neurofilament, prognostic biomarkers, disability progression, YKL-40.