What to do when the honeymoon wears off

Author: Regina Katzenschlager, Joaquim J Ferreira and K Ray Chaudhuri
Volume Info: Volume 7 Issue 2
Article Information

Volume 7 Issue 2 January 2022, pages 19-27
Received 15th November 2021; Accepted 1st December 2021

Regina Katzenschlager –  Department of Neurology and Karl Landsteiner Institute for Neuroimmunological and Neurodegenerative Disorders, Vienna, Austria

Joaquim J Ferreira –  Faculty of Medicine, University of Lisbon, and CNS – Campus Neurológico, Torres Vedras, Lisbon, Portugal.

K Ray Chaudhuri –  Parkinson’s Foundation Centre of Excellence at King’s College Hospital and King’s College London, London UK

Abstract:


We highlight key messages from a satellite symposium at the International Congress of Parkinson’s Disease and Movement Disorders (MDS) 2021, which reviewed the challenges of wearing-off in Parkinson’s disease (PD), focusing on both motor fluctuations and – what is often considered the hidden side of wearing-off – non-motor fluctuations (NMF). We consider the catechol-O-methyltransferase (COMT) inhibitor opicapone in the management of motor fluctuations, and consider evidence for a role for COMT inhibition in treating NMF, as well as presenting ongoing studies that may help to elucidate this further. The practicalities of adding opicapone 50 mg to a patient’s regimen to treat end-of-dose wearing-off are discussed by the faculty.

Keywords:


PARKINSON’S DISEASE, COMT INHIBITORS, OPICAPONE, MOTOR FLUCTUATIONS, NON-MOTOR FLUCTUATIONS

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